Aspiration Pneumonia Due to Clozapine-Induced Sialorrhea.

Trihexyphenidyl (benzhexol) in clozapine-induced nocturnal enuresis and sialorrhea.

Sir, Clozapine is an atypical antipsychotic medication. It is the agent of choice to treat patients with schizophrenia who are treatment-resistant and who are prone to extrapyramidal symptoms. However, besides occasional serious and life-threatening side effects like agranulocytosis, myocarditis, and seizures, clozapine is often discontinued because of many common and troublesome side effects l...

Sublingual atropine for the treatment of severe and hyoscine-resistant clozapine-induced sialorrhea.

University at Buffalo School of Pharmacy and Pharmaceutical Sciences Drug Information Response Documentation

Background: Clozapine is an atypical antipsychotic that differs from typical and other atypical antipsychotics as well. It differs from typical antipsychotics due to its low incidence of extrapyramidal symptoms and slight effect on dopamine sensitive prolactin. Another factor that makes it unique from most antipsychotic medications is its indication for treatment-refractory schizophrenia. This ...

A natural study of the efficacy of replacement medications for the treatment of clozapine-induced hypersalivation.

Unexpected Salivary Secretory Effects of Some "atypical" Antipsychotics

Antipsychotics are generally associated with dry mouth and deterioration of the oral health. However, clozapine, the archetype of the atypical antipsychotics, is reported to induce not only mouth dryness but also, in about one-third of the patients, hypersalivation, the latter resulting in disturbed sleep, coughing and choking sensations during the night and drooling during the day. Nevertheles...